Therapeutic role of aqueous extract of Milk thistle (Silybum adans, L.) and Burdock (Arctium lappa) in hyperglycemic rats.
Abstract
Bakground: Diabetes mellitus (DM), the third killer of the mankind health along with cancer, cardiovascular and cerebrovascular diseases, is one of the most challenging diseases facing health care professionals today Opjective: Therapeutic role of acques extract of Milk thistle (Silybum adans, L.) and Burdock  (Arctium lappa) and their mixture in hyperglycemic rats. Material and methods: Forty mature male albino rats weighing 180-200g then divided into 8 equal groups; one group was kept as a (C –ve) group, while the other 7 groups were injected s/c by 150 mg/kg body weight alloxan to induce hyperglycemia. Hyperglycemic rats were disparted into seven equal groups (n= 5 rats) one of them left as control positive while other eight groups orally fed using two doses (250 and 500 mg/kg of milk thistle, burdock , and mixture of them, respectively). At the end of experimental period (45 days), blood samples were collected for serum separation to determine serum glucose, liver enzymes (ALT, AST, ALP,) total protein, albumin, globulin, total cholesterol, triglycerides, lipoprotein fractions (HDLc, LDLc and VLDLc), kidney function (creatinine, urea and uric acid) and histopathological changes. Resultes: Data showed that that acques extract of milk thistle (Silybum adans, L.) and burdock  (Arctium lappa) milk thistle  and burdock  showed a significant decrease in serum glucose and improving liver and kidney status specially the mixture of 500 mg of milk thistle snd burdock . Conclusion: According to these results, milk thistle and burdock  could be used for hyperglycemia and impaired liver and kidney function.
Keywords
References
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DOI: http://dx.doi.org/10.14259%2Fbmc.v2i2.135
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