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Role of Abrus precatorius Linn. in indomethacin induced gastric ulcer in rats

Prasanta Kumar Mitra

Abstract


Role of Abrus precatorius Linn. in indomethacin induced gastric ulcers was studied in rats. Abrus precatorius Linn. leaves significantly reduced ulcer index induced by indomethacin. The plant leaves produced gastric anti secretory effect by decreasing gastric volume and acidity  It further increased gastric mucin which showed gastric cytoprotective effect. The plant prevented the increased lipid peroxidation during ulceration by indomethacin. Activities of the anti oxidant enzymes were enhanced during ulceration by this plant leaves. Results were comparable to that of ranitidine, a standard anti ulcer drug. Anti ulcerogenic activity of Abrus precatorius Linn. leaves was, thus, mediated through anti oxidant defense mechanism. 


Keywords


Abrus precatorius Linn, indomethacin, ranitidine, gastric ulcer, SOD, CAT, GSH

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DOI: http://dx.doi.org/10.14259%2Fpm.v2i3.128

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