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Chemical compounds and some acute toxicological parameters of Bauhinia platypetala

Francisco José Borges dos Santos, Joaquim S. da Costa Júnior, Antonia AC de Almeida, Maria do CG Lustosa, Johanssy da S Oliveira, Paulo MP Ferreira, Rivelilson Mendes de Freitas

Abstract


Bauhinia platypetala Burch Leguminosae is widely used in Brazil as a medicinal agent for treating diabetes, parasitic infestations, and also acts as a diuretic. This study investigated the safety of ethanol extract (EE) and the ethereal (EF), aqueous (AF), and ethyl acetate (EA) fractions from B. platypetala, determining their toxicological effects in mice. For each experiment, mice were randomly divided into five groups: control group treated with vehicle, four groups were treated 30 min before the behavioral tests and acute toxicity with only one dose of EE, EF, AF and EA (0.05 g/kg), and a reference group treated with DZP 0.001 g/kg. In EF, EA, and AF fractions the main components were phytol, stearic acid and myo-inositol, respectively. Our experiments could not determine the ED50, since no death was detected in acute toxicological tests. Ethanol extract and fractions did not cause alteration in motor activity, behavioral and respiratory rates. In open field test, only EE decreased the number of square crossed. Acute administration of the B. platypetala produces no change of hematological and biochemistry parameters. Collectively, the results indicate that the extract and fractions from B. platypetala may be atoxic, showing that this can be used as a folk medicine.


Keywords


Acute toxicity; Bauhinia platypetala Burch; Behavior; Biochemical parameters; Ethanol extract; Hematological parameters.

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References


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DOI: http://dx.doi.org/10.14259%2Fpm.v1i2.28

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