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Absence of interceptive effect in female Wistar rats exposed to Jacaranda decurrens during organogenesis period

Andrea Luiza Cunha-Laura, Rodrigo Juliano Oliveira, Claudia Andrea Lima Cardoso, Maria do Carmo Vieira, Sarah Alves Auharek

Abstract


Jacaranda decurrens subsp. symmetrifoliolata Farias and Proença (Bignoniaceae) popularly known as “carobinhaâ€, “carobinha-do-campo†or “carobaâ€Â  is used in folk medicine as a blood cleanser, wound healing and to treat uterus and ovary inflammations. In order to evaluate the reproductive performance and embryotoxic effects of the Jacaranda decurrens during organogenic period, the pregnant Wistar rats received, via gavage, 27.5 mg/Kg/day of aqueous extract. The control group received only distillate water. No clinical signs of maternal toxicity were observed and the term fetuses dis not present malformations or anomalies. Our results suggest that Jacaranda decurrens aqueous extract, in these experimental conditions, seems not to cause embryo deaths, growth retardation, and/or malformations in Wistar rats.


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DOI: http://dx.doi.org/10.14259%2Fpm.v1i1.33

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