Current status of Indian Medicinal Plants with Immunomodulatory potential - A Review
Abstract
Every country in the world has lists of herbal remedies for the treatment of diseases and different other unwanted conditions in humans. Ayurveda is one of the traditional systems of medicine practiced in India and Sri Lanka and can be traced back to 6000 B.C. Modulation of immune responses to alleviate the diseases has been of interest for many years and the concept of 'Rasayana' in Ayurveda is based on related principles. Rasayana is helpful to improve immunity and is normally advised during the degenerative phase of life, which starts from around 45 years in both males and females. Some of the medicinal plants valued in Ayurvedic Rasayana like Asparagus racemosus, Achillea wilhelmsii, Acacia catechu, Adhatoda vasica, Aloe vera, Amophophallus companulatus, Azadirachta indica, Bauhinia variegate, Bergenia stracheyi, Capparis zeylanica, Carica papaya, Chlorophytum arundinaeceum, Centella asiatica, Curcuma longa, Dioscorea alata, Enicostemma axillare, Justica spicigera, Mangifera indica, Madhuca longifolia, Ocimum sanctum, Ricinus communis, Tinospora cordifolia, Toxicodendron pubescens, Zingiber officinale etc., are evaluated for their therapeutic potential and have been scientifically investigated with promising results. A number of plant-based principles have been isolated with potential immunomodulatory activity that can explain and justify their use in traditional medicine in the past and can form the basis for further research in the future as well. This work shall hopefully encourage researchers to undertake further work on medicinal plants with potential immunomodulatory activity.
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Sell S: Immunomodulation. In Immunology, Immunopathology and Immunity, Elsevier Science Publishing Company, Inc. New York, 1987; 655–683.
Patwardhan B, Kalbag D, Patki PS, Nagsampagi BA: Search of Immune Modulatory Agents: A Review. Indian Drugs 1990; 28 : 348-358.
Satoskar R.S. and Bhandarkar S.D: Pharmacology and Pharmacotherapeutics, PartI, 8th ed. Popular Prakashan, Bombay, India.1983.
Charak Samhita, Chikitsa Sthana 1:4, Shree Gulabkunverba Ayurvedic Society. Jamnagar, India, 1949.
Patwardhan B and Hooper M: Ayurveda and Future Drug Development. International J Altern Complem Med 1992; 10 : 9-10.
Rita rezzani: Cyclosporine A and Adverse Effects on Organs: Histochemical Studies. Prog Histochem Cyto 2004; 39:85–128.
http://dx.doi.org/10.1016/j.proghi.2004.04.001
Chulet R and Pradhan P: A review on Rasayana. Phcog Rev 2010; 3 : 229e34.
Tolba R.H, Wrigge B, Machein U, Minor T, Kalff JC, Hirner A, Wolff M : Conversion to Neoral for Tacrolimus-Related Adverse Effects in Liver Transplant Recipients and Improvement in Quality of Life. Transplantion 2001; 33:3446–3447.
Chopra R.N, Nayar S.L and Chopra I.C: Glossary of Indian Medicinal Plants. CSIR, New Delhi; 2005.
Chopra R.N, Chopra L.C, Handa K.D, and Kapur L.D: Indigenous Drugs of India, 2nd ed. Kolkata: M/S Dhar, V.N. and Sons. 1982.
Nadkarni K.M, Nadkarni, A.K: Indian Materia Medica, 3rd edition. Mumbai: M/S Popular Prakasan Pvt. Ltd.2009.
Kirtikar K.R, Basu, B.D, Indian Medicinal Plants, 2nd ed. New Connaught Place, Dehradun, Indian. 2012.
Zhao T.F, Wang X, Rimando A.M and Che C: Folkloric Medicinal Plants: Tinospora sagittata var. cravaniana and Mahonia bealei. Planta Med 1991; 57: 505-510.
http://dx.doi.org/10.1055/s-2006-960188
PMid:1798808
Manish Gautam, Santanu Saha, Sarang Bani, Kaul A, Sanjay Mishra, Dada Patil, Satti N.K., Suri K.A., Sunil Gairola, Suresh K et al.: Immuno adjuvant potential of Asparagus racemosus aqueous extract in experimental system. J Ethnopharmacol 2004; 91:251–255.
http://dx.doi.org/10.1016/j.jep.2003.12.023
PMid:15120447
Mayank Thakur, Connellan Paul A, Myrna A.D, Carol Moriis A, Werner Praznik, Loeppert, Dixit et al: Characterization and in vitro immune modulatory screening of fructo-oligosaccharides of Asparagus racemosus Willd. Int J Biol Macromol 2012; 50:77– 81.
http://dx.doi.org/10.1016/j.ijbiomac.2011.09.027
PMid:22001723
Fariba sharififar, Shirin pournourmahammadi and Moslem Arabnejad: Immunomodulatory activity of aqueous extract of Achillea wilhelmsii C.Koch in mice. Indian J Exp Biol 2009, 47:668-671.
PMid:19775073
Syed Ismail and Mohammed Asad: Immuno modulatory activity of Acacia catechu. Indian J Physiol Pharmacol 2009; 53:25–33.
PMid:19810573
Vinothapooshan G and Sundar K: Immuno modulatory activity of various extracts of Adhatoda vasica Linn. in experimental rats. African J Pharm Pharmacol 2011, 5:306-310.
Jyotsana madan, Arun kumar Sharma, Nazma Inamdar, Harwinder Singh Rao, Ramnik Singh: Immuno modulatory properties of Aloe vera gel in mice. Int J Green Pharm 2008 2:152-154.
Tripathi AS, Chitra V, Sheikh NW, Mohale DS and Dewani AP: Immuno modulatory Activity of the Methanol Extract of Amorphophallus campanulatus (Araceae) Tuber. Trop J Pharm Res 2010, 9: 451- 454.
http://dx.doi.org/10.4314/tjpr.v9i5.61055
Shakti N. Upadhyay, Suman Dhawan, Sanjay Garg, GP. Talwar: Immuno modulatory effects of neem (Azadirachta indica) oil, Ann Limnol 1992; 14:1187-1193.
Sai Ram M, Sharma S.K, Ilavazhagan G, Devendra Kumar, Selvamurthy W : Immuno modulatory effects of NIM-76, a volatile fraction from Neem oil. J Ethnopharmacol 1997; 55:133-139.
http://dx.doi.org/10.1016/S0378-8741(96)01487-0
Ghasias M.M, Shaikh S.A, Deshpande A.D: Evaluation of the immuno modulatory activity of the ethanolic of the stem bark of Bauhinia variegate Linn. Int J Green Pharm 2006; 3:70-74.
http://dx.doi.org/10.4103/0973-8258.49379
Nighat Nazir, Surrinder Koul, Mushtaq Quireshi, Sachin C Taneja, Sheikh F Ahmed, Sarang Bani, Ghulam N Qazi : Immuno modulatory effect of bergenin and norbergenin against adjuvant-induced arthritis - A flow cytometric study. J Ethnopharmacol 2007; 112:401–405.
http://dx.doi.org/10.1016/j.jep.2007.02.023
PMid:17408893
Ghule BV, Murugananthan G, Nakhat PD, Yeole PG: Immunostimulant effects of capparis zeylanica Linn. Leaves. J Ethanopharmacol 2006; 108:311-315
http://dx.doi.org/10.1016/j.jep.2006.03.041
PMid:16766150
Noriko Otuski, Nam H Dang, Emi Kumagai, Akira Kondo, Satoshi Iwata, Chikao Morimoto: Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immune modulatory effects. J Ethnopharmacol 2010; 127:760–767.
http://dx.doi.org/10.1016/j.jep.2009.11.024
PMid:19961915
Ananth kumar K, Chitra, Leela Krishna V, Soujanya J: Evaluation of immune modulatory effect of hydroalcoholic root extract of Chlorophytum arundinaeceum baker in mice. Int J Pharm Pharm Sci 2011; 3:355-359.
Jayathirtha M.G, Mishra S.H: Preliminary immune modulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine 2004; 11: 361–365.
http://dx.doi.org/10.1078/0944711041495236
PMid:15185851
Mahuya Sengupta, Gauri Dutta Sharma, Biswajit Chakraborty : Hepatoprotective and immune modulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. Asian Pac J Trop Med 2011, 3: 193-199.
Grace G.L. Yu, Ben C.L,Chan, Clara B.S.Lau.: Immuno stimulatory activities of polysaccharide extract isolated from Curcuma longa. Int J Biol Macromol 2010, 47:342–347.
http://dx.doi.org/10.1016/j.ijbiomac.2010.05.019
PMid:20609432 PMCid:PMC2917522
Yen-Wenn Liu, Shang H.F, Wang C K, Hsu F.L, Hou W.C : Immuno modulatory activity of dioscorin, the storage protein of yam (Dioscorea alata cv. Tainong No. 1) tuber. Food Chem Toxicol 2007, 45:2312–2318.
http://dx.doi.org/10.1016/j.fct.2007.06.009
PMid:17637490
Saravanan S, Prakasn Babu N, Pandikumar P, Karunai Rai M, Gabriel Paulraj M, Ignacimuthu S: Immuno modulatory potential of Enicostema axillare (Lam.) A. Raynal, a traditional medicinal plant. J Ethnopharmacol 2012, 140:239– 246.
http://dx.doi.org/10.1016/j.jep.2012.01.010
PMid:22285523
Angel Josabad Alonso-Castro, Ortiz-Sanchez E, Dominquez F, Arana-Argaez V, Juarez-Vazquez Mdel C, Chavez M,Carranza-Alvarez C, Gaspar-Ramirez O, Espinosa-Reyes G, Lopez-Toledo G, Ortiz-Ardrade R, Garcia Carranca A : Antitumor and immune modulatory effects of Justicia spicigera Schltdl (Acanthaceae). J Ethnopharmacol 2012, 141: 888– 894.
PMid:22465146
Neelam Makare, Subhash Bodhankar, Vinod Rangari.: Immuno modulatory activity of alcoholic extract of Mangifera indica L. in mice. J Ethnopharmacol 2001, 78:133–137.
http://dx.doi.org/10.1016/S0378-8741(01)00326-9
Reena Purohit, Santosh Kr Singh, Asima Shaban, Rajesh nautiyal, Purohi M.C, Satish K.Verma : Immunomodulatory activity of Madhuca longifolia. Der Pharmacia Sinica, 2012, 3:153-155
Nayak S, Mengi S.: Immunostimulant activity of noni (Morinda citrifolia) on T and B lymphocytes. Pharma Biol 2010, 48:724-731.
http://dx.doi.org/10.3109/13880200903264434
PMid:20645768
Anjana Goel, Dilip Kumar Singh, Sandeep Kumar, Ashok Kumar Bhatia: Immuno modulating property of Ocimum sanctum by regulating the IL-2 production and its mRNA expression using rats splenocytes. Asian Pac J Trop Med 2010, 3 :8-12.
http://dx.doi.org/10.1016/S1995-7645(10)60021-1
Godhwani s, Godhwani JL, Vyas DS: Ocimum sanctum: an experimental study evaluating its anti-inflammatory, analgesic and antipyretic activity in animals. J Ethnopharmacol 1987, 21:153-163.
http://dx.doi.org/10.1016/0378-8741(87)90125-5
Godhwani S, Godhwani JL, Vyas DS: Ocimum sanctum: a preliminary study evaluating its immunoregulatory profile in albino rats. J Ethnopharmacol 1988, 24:193-198.
http://dx.doi.org/10.1016/0378-8741(88)90151-1
Mediratta PK, Dewan V, Bhattacharya SK, Gupta VS, Maiti PC, Sen P: Effect of Ocimum sanctum Linn. On humoral immune response. Indian J Med Res 1988, 87: 384-386
PMid:3169894
Mediratta P.K, Sharma K.K, Surender Singh: Evaluation of immune modulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. J Ethnopharmacol 2002, 80:15–20.
http://dx.doi.org/10.1016/S0378-8741(01)00373-7
Shankar mondal, Varma S, Bamola VD, Naik SN, Mirdha BR, Padhi MM, Mehta N, Mahapatra SC: Double-blinded randomized controlled trial for immune modulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteer. J Ethnopharmacol 2011, 136: 452– 456.
http://dx.doi.org/10.1016/j.jep.2011.05.012
PMid:21619917
Aravind kumar, Vaishali Singh, Sourav Ghosh: An experimental evaluation of In vitro immune modulatory activity of isolated compounds of Ricinus communis on human neutrophils. Int J Green Pharm 2011, 5: 201-204.
http://dx.doi.org/10.4103/0973-8258.91228
Maurya R, Wazir V, Kapil A, Kapil R.S: Cordifolisides A and B, two new phenylpropene disaccharides from Tinospora cordifolia possessing immune stimulant activity. Nat Prod Lett 1996, 8: 7–10.
http://dx.doi.org/10.1080/10575639608043231
Kapil A, Sharma S: Immuno potentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997, 58:89–95.
http://dx.doi.org/10.1016/S0378-8741(97)00086-X
Cho J.Y, Nam K.H, Kim A.R, Park J, Yoo E.S, Baik K.U, Yu Y.H, Park M.H : In vitro and In vivo immune modulatory effects of syringin. J Pharm Pharmacol 2001, 53: 1287–1294.
http://dx.doi.org/10.1211/0022357011776577
PMid:11578112
Upendra sharma et al: Immuno modulatory active compounds from Tinospora cordifolia. J Ethnopharmacol 2012, 141:918– 926.
CR Patil et al: Immuno modulatory activity of Toxicodendron pubescens in experimental models. Homeopathy 2009, 98:154–159.
http://dx.doi.org/10.1016/j.homp.2009.02.011
PMid:19647209
Hua-li Zhou, Yang-mei Deng, Qiang-min Xie: The modulatory effects of the volatile oil of ginger on the cellular immune response In vitro and In vivo in mice. J Ethnopharmacol 2006, 105:301–305.
http://dx.doi.org/10.1016/j.jep.2005.10.022
PMid:16338110
DOI: http://dx.doi.org/10.14259%2Fpm.v1i2.39
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