Wound Healing Effects Of The Leaves Extract Of Aspilia africana On Wistar Rats (Rattus norvegicus)
Abstract
Background: The leaves extract of Aspilia Africana was studied for its potency on experimentally induced wound in rats.
Aim : To investigate the effectiveness of Aspilia Africana as a wound healing agent.
Methods: Wounds were inflicted on wistar rats using excision model. 20 male wistar rats (two groups of 10 control and 10 experimental rats) were used for this study. The wounds were processed for histological analysis. Healing was assessed by wound contraction rate, complete day of wound closure and histological analysis of excised tissue.
Result: The wound contraction rates of experimental group on day 6 and 9 were statistically significant (P< 0.05). The mean wound closure for the experimental group was 12.6±1.17cm while that of the control group was 15.0±1.86cm. Concentration of neutrophils and macrophages were intense in experimental group than the control group in tissue samples excised on day 6. Also, the experimental group exhibited more intense concentration of neutrophils, macrophages, fibroblasts and capillaries on day 9 than the control group. It was observed that shorter period of total wound closure and increased inflammatory response corroborate the use of Aspilia Africana in the topical management of wound area with time.
 Conclusion: This study has indicated that extracts of leaves of Aspilia Africana have good potentials for use in wound care and further provide a rationale for the use of the leaves of this plant in wound management.
Keywords
References
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DOI: http://dx.doi.org/10.14259%2Fpm.v2i1.59
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